System Requirements
You will need Sun's Java 2 (or 5), or a Java 2 which includes Sun's JPEG routines, "com.sun.image.codec.jpeg". It is relatively easy to download, and instructions are given below. Apart from that, your system limits only the time taken to "Unshake" an image, and the size of image which can be processed: On a Gigahertz PC with 256 MByte of RAM, it should take less than 5 seconds for a 256 by 256 pixel image, and 4 times that for a 512 by 512 image. On a 300 Megahertz PC, it takes about 3 times as long, and on my little 75 Megahertz PC it used to take nearly 15 minutes for a 512 by 512 pixel image!

RAM is also a consideration: My little PC only had 64 MByte of RAM, so it slowed down a lot if I did anything else with it while it was processing a 512 by 512 pixel image.

So the conclusion is: If you can run Java 2, you can run Unshake, though if you have a small or slow computer, you will have to be patient. A newly bought PC should have no trouble at all running the code.

Unshake is really rad. But like all truely rad pieces of code it's got the world's worst UI.

--timball

Installation

based activation motif (ITAM)-like sequence and two consensus immunoreceptor tyrosine-based inhibitory motifs (ITIM) in its cytoplasmic region. To evaluate its signaling potential, we expressed constructs for chimeric molecules composed of the cytoplasmic region of FCRL5 and the extracellular and transmembrane regions of the IgG Fc receptor Fc{gamma}RIIB in a B cell line lacking an endogenous Fc receptor. Coligation of this fusion protein with the B cell receptor (BCR) inhibited BCR-mediated calcium mobilization, intracellular tyrosine phosphorylation, and Erk kinase activation. Our mutational analysis indicated that, whereas tyrosines in both the inhibitory and activation motifs are phosphorylated after ligation, only those in ITIMs influence BCR-mediated signaling. This FCRL5 inhibitory effect was mediated through dual ITIM recruitment of the SH2-containing protein tyrosine phosphatase, SHP-1, which in turn dephosphorylates the ITAM-based tyrosines in BCR Ig{alpha}/Igbeta heterodimers. An FCRL5 inhibitory effect on BCR signaling was likewise demonstrable for primary B cells. Although its ligand is presently unknown, we conclude that FCRL5 has the functional potential to serve as an inhibitory coreceptor on mature B cells in humans.

B cell receptor | Fc receptor-like protein 5 | inhibitory | SH2 domain-containing tyrosine phosphatase 1

B cell receptor (BCR) engagement initiates signaling cascades that lead to activation of the Ras-MAPK pathway, phosphatidylinositol-3-kinase, and phospholipase C {gamma} (PLC{gamma}) (1, 2). The BCR triggering ultimately induces gene expression patterns that can promote cell activation, apoptosis, or anergy, depending upon the balance of enhancing and inhibitory influences that vary according to the stage in B cell differentiation (3). Costimulatory or inhibitory coreceptors on B cells modulate BCR signaling to either enhance or attenuate downstream signaling cascades (4). Inhibitory coreceptors may dampen BCR signaling via an immunoreceptor tyrosine-based inhibition motif (ITIM) in their cytoplasmic region. When tyrosine phosphorylated, the ITIMs recruit protein tyrosine phosphatases and lipid phosphatases via Src homology 2 (SH2) domain binding to achieve down-regulation or neutralization of BCR-induced activation (5). Conversely, the costimulatory receptors may have their own cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAM) or they may pair with a transmembrane protein containing one or more ITAMs, whose tyrosines are phosphorylated by src family kinases to allow the recruitment of signaling molecules that promote cellular activation (6). The balance between activating and inhibitory receptor influences can be complicated by their coexpression on individual B cells. Moreover, individual cell surface receptors may possess both activating and inhibitory motifs; their differential engagement, according to ligand specificity and affinity, may trigger inhibitory and/or ac... [ Read More (0.3k in body) ]

Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment -- Haga et al. 104 (23): 9770 -- Proceedings of the National Academy of Sciences

What is Bikely?

Put very simply, Bikely helps cyclists share knowledge of good bicycle routes.

It can be quite tricky traversing a car dominated city by bicycle, particularly when you need to travel an unknown route to a new destination.

But the chances are, someone has cycled that way before you. Bikely makes it easy for him or her to show you the best way.
Bikely needs you!

Bikely is young and growing fast. But it still needs more people like you to submit your favorite bike paths.

As we collect more and more routes, Bikely can become an incredibly useful resource for the cycling community!

Membership is free, fast and easy. So join now »

Or if motorbikes are more your thing, check out our motorcycle routes on MotoWhere.

User submitted and built bicycle paths and trail/road notes for all your commuting/recreational needs. I'm gonna start posting my routes w/ all the places to eat on the way.

--timball

Bike Trails, Paths & Routes From Over 40 Countries at Bikely.com

I NEED THIS BUTTON!

--timball

"Terrorist Buster" Logo — Central Intelligence Agency

A court hearing officer ordered Mr. Scaife to pay his estranged wife $725,000 a month in preliminary temporary support shortly after she filed for divorce early last year. The amount was derived from a standing formula in the law that places temporary support at 40 percent of a husband's income.

GET A PRE-NUP

--timball

Millions up for grabs in Scaife divorce fight

• Like Lotus Cars, Obvio ! cars are designed by drivers for drivers, adding lightweight with unparalleled handling

• Monocoque integrated aluminum chassis design includes composites passengers safety cell utilizing “Niess Elliptical Survival Rings”

• High performance, microsport car with seating for three, side-by-side

• All laminated safety glass tinted windows, front and side impact airbags

• No more parallel parking, fits lengthwise into the width of most parking spots

It's god aweful... I want one SOOOO bad.

--timball

Obvio ! model 828 specs

I finally ate at the Southern Kitchen in New Market VA. It's just off of I-81 in the middle of VA and it's GOOD. The best thing I had there was their "peanut soup". Imagine a sufrito w/ smashed up boiled peanuts... It's crazy good.

--timball

Southern Kitchen @ HollyEats.com

so yesterday I asked Vanessa to marry me and she said yes! I'm so happy and excited, so spread the word...the wedding will probably be sometime in fall of 2008, other than that I don't really have any details yet...

--Mike

I'm engaged

There's good news for those of us who were dismayed at the cancellation of "Dead Like Me." The dark comedy about the trials and tribulations of a group of grim reapers may come back to life -- briefly, at least.

"Dead Like Me," the popular Showtime television series starring Mandy Patinkin and Ellen Muth, is returning as a made-for-DVD movie. MGM told Moviehole.com that Stephen Herek ("The Mighty Ducks") will direct the new film. There's no word yet on who’ll be starring in the film -- but hopefully they'll revive the original cast.

Okay seriously "Dead Like Me" remains one of my favorite shows along the lines of such things as Homicide: Life on the Street or Studio 60 -- on the Sunset Strip. And it ain't just cause Ellen Muth is hot. Nor is it because Mandy Patinkin is Inigo Montoya and someone killed his father and needs to prepare to die.

--timball

Science fiction news from SyFy Portal: Battlestar Galactica, Heroes, Doctor Who, and more

I'm bored today so I desided to update my programming rules, make a 2.1 if you will, I know the smart ones out there never trust a 1.0 anyways...

My Rules (2.1):
1. Kludges that we'll fix in the next release never get fixed in the next release...

2. If you dont do it right now, you (or some poor bastard that replaces you) will have to do it right later...

3. It always costs more to do it later...

4. You're not going to have more funding for the next release. (thanks Decius)

5. Beware of anyone in a suit...

6. The man in charge usually didn't get there by being better than everyone else; keep that in mind.

7. If you don't talk to your customers to see what will make them happy, then sooner or later someone else will...

8. Sales guys can be powerful allies for interoffice BS, but if you make yourself too available they will never leave you alone...

9. Management has no idea what the customer wants...

10. Engineering has even less idea what the customer wants...

11. Assume every engineer you work with is an idiot, try not to let
on that you know...if you find engineers that are obviously not idiots, find a way to keep them...

12. Never outsource your core competency...

13. Lazyness and incompetence are contagious...

14. No-one cares if you read wikipedia all day every day if you get your work done on time...

15. If they do care, find another place to work...

16. Your code is not finished until you've tested it...

17. Never assume they have tested their code...

18. Simple regression testing is best done when its automated; its less error prone too.

19. Engineers that think lack of documentation is job security should be fired sooner rather than later (otherwise you'll make them right)...

20. Contrary to popular belief, third party libraries reduce portability of your code...

21. "Cool" is not a business case...

22. Engineerings job is to say yes, no matter how stupid management's requests are...good engineers find ways to say yes that spotlight their intelligence and managements stupidity...(e.g. if they ask you to turn lead into gold, tell them you will if they allocate a few trillian dollars and a fusion reactor)...

23. The night before its due is probably not the best time to start integrating your code in a large project...

24. You can be really good at your job, and a dick, or you can be so so at your job and a really nice guy...you cannot be a dick and bad at your job...

25. Time estimation is really hard...it will take longer than you think it will...

26. Demonstrating that your compeditors suck isn't enough to get anyone to buy your product...

27. Don't ship anything you're not proud of...

28. Your code will be used in ways you never thought of...plan accordingly...

29. If you can't settle on one way of doing something, do it both ways and make it a configur... [ Read More (0.7k in body) ]

My programming rules 2.1