The general rules of this game are no different from any other drinking game. A drink is either a shot or a good gulp from a beer (or cider). Different events call for different numbers of drinks and all you do is watch the speech and play along. If all goes well, you'll be unconscious by the time they show the other party's response.

It's that time again folks!

Remember to lay on your side so you don't choke on your vomit...

Update:

[20:27] In addition to whatever State of The Union drinking game you may be playing.. I have and addition.
[20:27] You must have one pre-prepared shot.
[20:28] Something you either really like, or that can hurt you badly. Your choice there.
[20:28] You drink it upon hearing the word "cybersecurity".
[20:28] Or, for that matter, anything cyber- that has to do with infosec.
[20:28] UNDERSTAND?

Update^2: So much for that...

The State of the Union Address Drinking Game 2008