Ira Glass: "Not enough gets said about the importance of abandoning crap."
Thank you!
Also noteworthy advice:
"If you're not failing all the time, you're not creating a situation where you can get super-lucky."
This excellent video interview is available in several parts on YouTube, or as a single video on current.tv, alongside other interviews with Robert Redford, Dave Eggers, Sarah Vowell, Elvis Mitchell, Catherine Hardwicke, Xeni Jardin, and others.