Our
brains may never be well-enough equipped to understand the universe
and we are fooling ourselves if we think they will.

Why should we expect to be able eventually to understand how the
universe originated, evolved, and operates? While human brains
are complex and capable of many amazing things, there is not necessarily
any match between the complexity of the universe and the complexity
of our brains, any more than a dog's brain is capable of understanding
every detail of the world of cats and bones, or the dynamics of
stick trajectories when thrown. Dogs get by and so do we, but do
we have a right to expect that the harder we puzzle over these
things the nearer we will get to the truth? Recently I stood in
front of a three metre high model of the Ptolemaic universe in
the Museum of the History of Science in Florence and I remembered
how well that worked as a representation of the motions of the
planets until Copernicus and Kepler came along.

I tend to not care for these guys, but this one is interesting.

The human brain and its products are incapable of understanding the truths about the universe