Oct. 24, 2005 — Exenatide (Byetta) appears to promote weight loss in patients with type 2 diabetes mellitus (DM2), according to new research findings. The drug is currently approved as a glucose control agent for type 2 diabetes when used in combination with metformin and/or sulfonylureas.

Exenatide helps maintain glucose control by mimicking the actions of glucagon-like peptide-1 (GLP-1), and it enhances glucose-dependent insulin secretion. The agent, the first in the class of incretin mimetics, has been shown to reduce glycated hemoglobin (HbA1c) levels in patients with DM2.

Many antidiabetic agents are associated with weight gain in patients with type 2 diabetes, who are often already overweight or obese. Thus, a weight loss effect with an antidiabetic agent would provide additional benefits when treating these patients.

The amplitude of my weight loss is 100 pounds. The period of the sine wave is 1.5 years. I am at the top of the sin wave. My doctor prescribed me this diabetic medication that will act as a "chemical gastric bypass," by making my belly feel full more quickly, because it will empty its contents slower. I inject with a pen-thing across my belly in 4 spots, 15 minutes before I eat. Thats it. 3 times a day you get that feeling of "stuffed" much more easily.

Since I'm already exercising, this should be very effective. I will let everyone know.

Exenatide Promotes Weight Loss in Overweight Diabetic Patients