] Of all our chromosomes, it is the only one that is ] permanently locked into the germ cells of men, where the ] frenzy of cell division and error-prone DNA copying ] required to keep up the daily output of 150 million sperm ] creates the ideal conditions for mutation. And it shows. ] Seven percent of men are infertile or sub-fertile and in ] roughly a quarter of cases the problem is traceable to ] new Y chromosome mutations, not present in their fathers, ] which disable one or other of the few remaining genes. ] This is an astonishingly high figure, and there is no ] reason to think things will improve in the future -- ] quite the reverse in fact. One by one, Y chromosomes will ] disappear, eliminated by the relentless onslaught of ] irreparable mutation, until only one is left. When that ] chromosome finally succumbs, men will become extinct. ] ] But when? I estimate that, at the current rate, male ] fertility caused by Y chromosome decay will decline to 1 ] percent of its present level within 5,000 generations -- ] roughly 125,000 years. Not exactly the day after ] tomorrow -- but equally, not an unimaginably long time ] ahead. This is a very entertaining article, particularly if you are into genetic engineering. How well accepted is this theory? On the death of Y chromosomes |