This is not your father's high school biology; the days are long since gone when "bio" meant taking a razor to an earthworm, frog, or fetal pig. Now, "bio" is applied pattern recognition ... cool hunting. The genetic divergence time between two species varies substantially across the genome, conveying important information about the timing and process of speciation. Here we develop a framework for studying this variation and apply it to about 20 million base pairs of aligned sequence from humans, chimpanzees, gorillas and more distantly related primates. Human–chimpanzee genetic divergence varies from less than 84% to more than 147% of the average, a range of more than 4 million years. Our analysis also shows that human–chimpanzee speciation occurred less than 6.3 million years ago and probably more recently, conflicting with some interpretations of ancient fossils. Most strikingly, chromosome X shows an extremely young genetic divergence time, close to the genome minimum along nearly its entire length. These unexpected features would be explained if the human and chimpanzee lineages initially diverged, then later exchanged genes before separating permanently.
Reread that last sentence for emphasis. I missed this paper on initial publication, but on recent review, and in the context of the Year in Ideas and yesterday's NYT profile of its lead author, I have to say this is the closest thing to a Gold Star biology paper as I have seen recently. If you've read The Ancestor's Tale, you'll recognize some of the analytical techniques applied here. |