Paul Graham:

When I encounter a startup with a lame-sounding idea, I ask "What Microsoft is this the Altair Basic of?"

Alastair Humphreys:

You must be willing to accept that things do not come about instantly. Too many people set the cart before the horse, seeking the honour and recognition but without first completing the hazardous journey on low wages in the bitter cold through long hours of complete darkness.

Horace Dediu:

Whether your approach and innovation sustains the hegemony or changes it will largely depend on your business model being asymmetric to the incumbent. Determining what is and isn't symmetric should be the first step in your analysis.

Richard Hamming:

Once you get your courage up and believe that you can do important problems, then you can. If you think you can't, almost surely you are not going to.

Decius:

It's important to understand that it isn't Congress that must change -- it is us.