Emily Eakin:

A year and a half ago, a few dozen physicians in the United States offered FMT. Today, hundreds do, and OpenBiome, a nonprofit stool bank founded last year by graduate students at M.I.T., ships more than fifty specimens each week to hospitals in thirty-six states. The Cleveland Clinic named fecal transplantation one of the top ten medical innovations for 2014, and biotech companies are competing to put stool-based therapies through clinical trials and onto the market. In medicine, at any rate, human excrement has become a precious commodity.

It's possible that no Americans have gut microbiomes that are truly healthy.

Stewart Butterfield:

I try to instill this into the rest of the team but certainly I feel that what we have right now is just a giant piece of shit. Like, it's just terrible and we should be humiliated that we offer this to the public. Not everyone finds that motivational, though.

Jon Bois:

Working at RadioShack was sort of the worst of two worlds: there was the poverty-level income of a blue-collar retail job, coupled with the expectations, political nonsense, and corporate soullessness of the white-collar environment.

Paul Ford:

The ultimate function of any standards body is epistemological; given an enormous range of opinions, it must identify some of them as beliefs. The automatic validator is an encoded belief system. Not every Web site offers valid HTML, just as not every Catholic eschews pre-marital sex. The percentage of pure and valid HTML on the web is probably the same as the percentage of Catholics who marry as virgins.

Paul Graham Raven:

We offload physical effort onto our technologies, but are hence increasingly obliged to engage in other forms of labour in order to sustain the infrastuctures on which those technologies depend; the increasing interdependencies of infrastructure act as multipliers of technological effectiveness, but as they do so they push us further out onto the brittle, skinny branches of the technological path-dependency tree.

Bob Lefsetz:

You're a student of the game. You believe since you're passionate, you deserve not only a chance, but success.

But the truth is everybody wants to play. And the sieve to success is extremely narrow. Because people don't have time for mediocre, they don't even have time for good!