There are a variety of different groups trying to break into computer networks today. Some of them are extremely sophisticated, while others barely understand how to use a command-line interface. Some have monetary and political motives, while others just do it for the “lulz.”
Each group presents a unique threat to the network environment, and there are different ways of responding to each. Tools like anti-virus have their purpose, but they can't address every problem.
I wrote this.